Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline.

  title={Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline.},
  author={Sarah L. Crittenden and Christian R Eckmann and Liaoteng Wang and David S. Bernstein and Marvin Wickens and Judith Kimble},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={358 1436},
During the development of multicellular organisms, the processes of growth and differentiation are kept in balance to generate and maintain tissues and organs of the correct size, shape and cellular composition. We have investigated the molecular controls of growth and differentiation in the Caenorhabditis elegans germline. A single somatic cell, called the distal tip cell, promotes mitotic proliferation in the adjacent germline by GLP-1/Notch signalling. Within the germline, the decisions… CONTINUE READING

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