Regulation of the mevalonate pathway

@article{Goldstein1990RegulationOT,
  title={Regulation of the mevalonate pathway},
  author={Joseph L. Goldstein and Michael S Brown},
  journal={Nature},
  year={1990},
  volume={343},
  pages={425-430}
}
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease. 

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