Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast.

@article{Wolf2010RegulationOT,
  title={Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1\{alpha\} and transforming-growth factor-\{beta\}3 in the human trophoblast.},
  author={Nadine M. Wolf and Wei Yang and Caroline E Dunk and Isabella Gashaw and Stephen James Lye and Thomas Ring and Markus Schmidt and Elke Winterhager and Alexandra Gellhaus},
  journal={Endocrinology},
  year={2010},
  volume={151 6},
  pages={2835-45}
}
It is known that a hypoxic environment is critical for trophoblast migration and invasion and is fundamental for appropriate placental perfusion. Because cysteine-rich 61 (CYR61, CCN1) and nephroblastoma overexpressed (NOV, CCN3) are expressed in the extravillous trophoblast and expression levels are deregulated in preeclampsia, we investigated their regulation properties in first-trimester placental explants and in JEG3 choriocarcinoma cells upon a physiological low oxygen tension of 1-3%. In… CONTINUE READING