Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.

@article{Lucas1999RegulationOT,
  title={Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors.},
  author={Ruth Lucas and Marc S Freedman and Marta Mu{\~n}oz and Jos{\'e} Manuel Garc{\'i}a-Fern{\'a}ndez and Russel G. Foster},
  journal={Science},
  year={1999},
  volume={284 5413},
  pages={505-7}
}
In mammals, ocular photoreceptors mediate an acute inhibition of pineal melatonin by light. The effect of rod and cone loss on this response was assessed by combining the rd mutation with a transgenic ablation of cones (cl) to produce mice lacking both photoreceptor classes. Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers. These data indicate that mammals have… CONTINUE READING

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