Regulation of the level of Vesl-1S/Homer-1a proteins by ubiquitin-proteasome proteolytic systems.

@article{Ageta2001RegulationOT,
  title={Regulation of the level of Vesl-1S/Homer-1a proteins by ubiquitin-proteasome proteolytic systems.},
  author={Hiroshi Ageta and Akira Kato and Shigetsugu Hatakeyama and Kei-ichi I Nakayama and Yasushi Isojima and Hiromu Sugiyama},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 19},
  pages={15893-7}
}
The vesl-1S/homer-1a gene is up-regulated during seizure and long term potentiation. Other members of the Vesl family, Vesl-1L, -2, and -3, are constitutively expressed in the brain. We examined the regulatory mechanisms governing the expression level of Vesl-1S protein, either an exogenously introduced one in COS7 or human embryonic kidney 293T cells or an endogenous one in rat brain neurons in cultures. In both cases, application of proteasome inhibitors increased the amount of Vesl-1S… CONTINUE READING

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