Regulation of the level of S-adenosylmethionine decarboxylase during lymphocyte mitogenesis.

@article{Morris1981RegulationOT,
  title={Regulation of the level of S-adenosylmethionine decarboxylase during lymphocyte mitogenesis.},
  author={D. R. Morris and Jay L. Degen and O E Oleinik and Christine E. Seyfried},
  journal={Medical biology},
  year={1981},
  volume={59 5-6},
  pages={
          314-9
        }
}
Bovine lymphocytes were mitogenically activated by the lectin concanavalin A and the activity of the polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SDC), was followed (R. H. Fillingame and D. R. Morris, Biochem. Biophys. Res. Commun. 52: 1020-1025, 1973). Enzyme activity began to increase at approximately 3 hours after cellular activation, reaching a peak at 9-12 hours. A second elevation of SDC activity coincided with the entry of the cells into S phase at 24 hours. The… CONTINUE READING