Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells.

@article{Clavel2010RegulationOT,
  title={Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells.},
  author={St{\'e}phan Clavel and Sandrine Siffroi-Fernandez and Anne Sophie Coldefy and Kim E. Boulukos and Didier F Pisani and Beno{\^i}t D{\'e}rijard},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 2},
  pages={470-80}
}
Muscle atrophy is a debilitating process associated with many chronic wasting diseases, like cancer, diabetes, sepsis, and renal failure. Rapid loss of muscle mass occurs mainly through the activation of protein breakdown by the ubiquitin proteasome pathway. Foxo3a transcription factor is critical for muscle atrophy, since it activates the expression of ubiquitin ligase Atrogin-1. In several models of atrophy, inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway induces… CONTINUE READING

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