Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma.

@article{Meier2002RegulationOT,
  title={Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma.},
  author={Christoph Anton Meier and Rachel Chicheportiche and Cristiana E. Juge-Aubry and Magali G Dreyer and Johanna Dayer},
  journal={Cytokine},
  year={2002},
  volume={18 6},
  pages={
          320-8
        }
}
Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, which is tightly regulated by multiple factors. The peroxisome proliferator-activated receptors (PPARs) were shown to be involved in modulating inflammation. PPARgamma is activated by… CONTINUE READING
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