Regulation of the inositol 1,4,5-trisphosphate-activated Ca2+ channel by activation of G proteins.

@article{Xu1996RegulationOT,
  title={Regulation of the inositol 1,4,5-trisphosphate-activated Ca2+ channel by activation of G proteins.},
  author={Xiaohong Xu and Wei-sen Zeng and Shmuel Muallem},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 20},
  pages={
          11737-44
        }
}
Streptolysin O-permeable pancreatic acini were used to study the regulation of the inositol 1,4,5-trisphosphate (IP3)-activated Ca2+ channel (IPACC) by agonists and antagonists. Measurements of the apparent affinity for IP3 (KappIP3) showed that the IPACC is dynamically controlled during cell stimulation and inhibition, i.e. agonists decreased and antagonists increased KappIP3. KappIP3 was also independently regulated by thimerosal, Ca2+ content of the stores, the incubation temperature… CONTINUE READING
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