Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD 34 1 cells by hematopoietic growth factors : implication of survivin expression in normal hematopoiesis

The inhibitor-of-apoptosis protein survivin is expressed in most cancers and leukemias and during fetal development, but not in most normal adult tissues. Survivin expression was analyzed in umbilical cord blood (UCB) and adult bone marrow CD34 1 cells and in the factordependent MO7e cell line; also investigated was whether survivin expression was regulated… CONTINUE READING