Regulation of the immunoglobulin heavy chain locus expression at the phylogenetic level of a bony fish: transcription factor interaction with two variant octamer motifs.

@article{Hikima2006RegulationOT,
  title={Regulation of the immunoglobulin heavy chain locus expression at the phylogenetic level of a bony fish: transcription factor interaction with two variant octamer motifs.},
  author={Jun-ichi Hikima and Mara L. Lennard and Melanie R. Wilson and Norman W. Miller and Gregory W. Warr},
  journal={Gene},
  year={2006},
  volume={377},
  pages={119-29}
}
Transcriptional control of the IGH locus in teleosts is not fully understood, but evidence from catfish and zebrafish indicates major roles for octamer-binding (Oct) and E-protein transcription factors. A pair of variant octamer motifs in the Emu3' enhancer of the catfish has been shown to be particularly important in driving expression, justifying detailed study of their function. These octamer motifs were examined to determine if they bound Oct2 POU domains in monomeric or dimeric (PORE and… CONTINUE READING
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