Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype

@article{Soloway1991RegulationOT,
  title={Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype},
  author={Prof. Roger D. Soloway and Susan Fish and Howard C. Passmore and M A Gefter and R Lane Coffee and Tim L Manser},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={847 - 858}
}
The immunodominant CD4 T cell epitope of the bacteriophage lambda cI repressor protein in several inbred mouse strains can be represented by a peptide encompassing amino acids 12-26. Here, we show that this peptide, and a variety of its sequence variants, can induce immediate-type hypersensitivity in mice. 12-26 variants that differ by as little as single amino acid residues deviate greatly in their ability to induce hypersensitivity. Further, differences in major histocompatibility complex… CONTINUE READING