Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6

@article{Graham2013RegulationOT,
  title={Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6},
  author={Gerard J. Graham and Massimo Locati},
  journal={The Journal of Pathology},
  year={2013},
  volume={229}
}
Chemokines and their receptors are key regulators of leukocyte migration and intra‐tissue accumulation under both homeostatic and inflammatory conditions. Regulation of chemokine‐dependent responses, particularly those relating to inflammation, is essential to avoid the development of inflammatory and autoimmune pathologies. Recently, a new subfamily of chemokine receptors referred to as the 'atypical' chemokine receptors has emerged, members of which have been shown to play important roles in… 
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References

SHOWING 1-10 OF 102 REFERENCES
D6 and the atypical chemokine receptor family: Novel regulators of immune and inflammatory processes
  • G. Graham
  • Biology, Medicine
    European journal of immunology
  • 2009
TLDR
The in vitro and in vivo biology of D6 is described, which indicates that D 6 is active as a scavenger of inflammatory CC‐chemokines and appears to play essential roles in the regulation of inflammatory responses.
Increased inflammation in mice deficient for the chemokine decoy receptor D6
TLDR
D6–/– mice showed an anticipated and exacerbated inflammatory response in a model of skin inflammation and the absence of D6 resulted in increase cellularity and inflammatory‐chemokine levels in draining lymph nodes, suggesting that D6 is a decoy receptor structurally adapted and strategically located to tune tissue inflammation and control transfer of inflammatory chemokines to draining lymph node.
Role of the chemokine scavenger receptor D6 in balancing inflammation and immune activation.
TLDR
The expression and regulation of D6 during challenge with the pathogen, and its role in dampening inflammation in tissues and draining lymph nodes and in the organization of a protective immune response are discussed.
The Atypical Chemokine Receptor D6 Contributes to the Development of Experimental Colitis 1
TLDR
It is shown that D6 is expressed in the resting colon, predominantly by stromal cells and B cells, and is up-regulated during colitis, and can contribute to the development of colitis by regulating IL-17A secretion by γδ T cells in the inflamed colon.
Structure-function dissection of D6, an atypical scavenger receptor.
TLDR
By using the approaches outlined in this chapter, evidence has emerged that D6 acts as a chemokine scavenger which uses unique intracellular trafficking properties to continuously sequester extracellular chemokines into cells, and may also ultimately provide unprecedented insight into the structure of D6 and other chemokin receptors.
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells.
TLDR
This review presents the current understanding of the mechanisms that regulate the cellular perception and pathophysiologic meaning of chemokines and suggests that the specific patterns of homeostatic chemokine patterns are charting lymphocyte navigation routes for immune surveillance.
International union of pharmacology. XXII. Nomenclature for chemokine receptors.
TLDR
A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system.
Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection
TLDR
The D6 decoy receptor plays a key role in setting the balance between antimicrobial resistance, immune activation, and inflammation in M. tuberculosis infection.
Cardiac Allograft Rejection: Examination of the Expression and Function of the Decoy Chemokine Receptor D6
TLDR
The first examination of the biology of D6 during rejection is presented and an exciting new mechanism for the antiinflammatory actions of transforming growth factor-&bgr; is suggested.
The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.
TLDR
It is suggested that inhibiting D6 function might be a novel means to attenuate airway responses in individuals with allergic asthma because it reduces airway reactivity and increases inflammation.
...
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2
3
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