Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.

@article{Makkonen2009RegulationOT,
  title={Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.},
  author={Katri M Makkonen and Sanna M Pasonen-Sepp{\"a}nen and Kari J T{\"o}rr{\"o}nen and Markku I. Tammi and Carsten Carlberg},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 27},
  pages={
          18270-81
        }
}
The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making hyaluronan, altered concentrations of which are associated with many pathological situations including wounding, several inflammatory conditions, and malignant tumors. In this study we showed that HAS2 is a primary target of the cAMP activator forskolin and the nuclear hormone all-trans-retinoic acid (RA). The first 2250 bp of the promoter contain three response elements (REs) for the transcription factor CREB1 as well as… CONTINUE READING

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