Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements.

@article{Hawkes2014RegulationOT,
  title={Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements.},
  author={H Hawkes and Therese Christina Karlenius and Kathryn F Tonissen},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1840 1},
  pages={303-14}
}
BACKGROUND The thioredoxin system maintains redox balance through the action of thioredoxin and thioredoxin reductase. Thioredoxin regulates the activity of various substrates, including those that function to counteract cellular oxidative stress. These include the peroxiredoxins, methionine sulfoxide reductase A and specific transcription factors. Of particular relevance is Redox Factor-1, which in turn activates other redox-regulated transcription factors. SCOPE OF REVIEW Experimentally… CONTINUE READING

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