Regulation of the human telomerase reverse transcriptase gene

@article{Ducrest2002RegulationOT,
  title={Regulation of the human telomerase reverse transcriptase gene},
  author={Anne-Lyse Ducrest and Henrietta Szutorisz and Joachim Lingner and Markus Nabholz},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={541-552}
}
Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expression is due to their origin from telomerase positive stem cells or to reactivation of the gene during tumorigenesis. Telomerase negative cells lack detectable cytoplasmic and nuclear hTERT transcripts; in telomerase positive cells 0.2 to 6 mRNA… CONTINUE READING

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