Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains.

@article{Baydoun2007RegulationOT,
  title={Regulation of the human T-cell leukemia virus gene expression depends on the localization of regulatory proteins Tax, Rex and p30II in specific nuclear subdomains.},
  author={Hicham Hachem Baydoun and Madeleine Duc-Dodon and Sylvie Lebrun and Louis Gazzolo and Françoise Bex},
  journal={Gene},
  year={2007},
  volume={386 1-2},
  pages={
          191-201
        }
}
The human T-cell leukemia virus HTLV-1 encodes regulatory proteins, Tax, Rex and p30(II), which are involved in the control of viral gene expression at the transcriptional and post-transcriptional levels. Tax localizes in unique nuclear bodies that contain components of the transcription and splicing complexes. In this work, we studied the relative intracellular localizations of Tax, Rex and p30(II). Run-on transcription assays and immunocytochemistry at light and electron microscopy levels… CONTINUE READING

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  • 2019
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