Regulation of the human Na(+)-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1.

@article{Martn2000RegulationOT,
  title={Regulation of the human Na(+)-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1.},
  author={Mart{\'i}n G. Mart{\'i}n and Jiafang Wang and R. Sergio Solorzano-Vargas and Jason Tsz Hin Lam and Erin Turk and Ernest M Wright},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={278 4},
  pages={G591-603}
}
The Na(+)-glucose cotransporter (SGLT1) is expressed primarily by small intestinal epithelial cells and transports the monosaccharides glucose and galactose across the apical membrane. Here we describe the isolation and characterization of 5.3 kb of the 5'-flanking region of the SGLT1 gene by transiently transfecting reporter constructs into a variety of epithelial cell lines. A fragment (nt -235 to +22) of the promoter showed strong activity in the intestinal cell line Caco-2 but was inactive… CONTINUE READING

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