Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.

@article{Loiselle2004RegulationOT,
  title={Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.},
  author={Frederick B Loiselle and Patricio Eduardo Morgan and Bernardo V. Alvarez and Joseph R Casey},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 6},
  pages={C1423-33}
}
Human NBC3 is an electroneutral Na(+)/HCO(3)(-) cotransporter expressed in heart, skeletal muscle, and kidney in which it plays an important role in HCO(3)(-) metabolism. Cytosolic enzyme carbonic anhydrase II (CAII) catalyzes the reaction CO(2) + H(2)O left arrow over right arrow HCO(3)(-) + H(+) in many tissues. We investigated whether NBC3, like some Cl(-)/HCO(3)(-) exchange proteins, could bind CAII and whether PKA could regulate NBC3 activity through modulation of CAII binding. CAII bound… CONTINUE READING
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