Regulation of the human Fc epsilon RI alpha-chain distal promoter.

  title={Regulation of the human Fc epsilon RI alpha-chain distal promoter.},
  author={Masanari Hasegawa and Chiharu Nishiyama and Makoto Nishiyama and Yushiro Akizawa and Kyoko C Takahashi and Tomonobu Ito and Susumu Furukawa and Chisei Ra and Ko Okumura and Hideoki Ogawa},
  journal={Journal of immunology},
  volume={170 7},
The alpha-chain of the high affinity receptor for IgE (Fc epsilon RI) is essential for cell surface expression of Fc epsilon RI and binding of the IgE Ab. The human alpha-chain gene possesses two promoters: the proximal promoter, which is highly conserved with that of rodent; and the distal promoter, the structure and role of which are largely unknown. Transcriptional regulation of the alpha-chain distal promoter was investigated in this study. Transient reporter assay revealed critical region… CONTINUE READING

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