Regulation of the growth hormone (GH) receptor and GH-binding protein by GH pulsatility.

@article{Hochberg1993RegulationOT,
  title={Regulation of the growth hormone (GH) receptor and GH-binding protein by GH pulsatility.},
  author={Ze’ev Hochberg and M. Phillip and Moussa B. H. Youdim and Tamar Amit},
  journal={Metabolism: clinical and experimental},
  year={1993},
  volume={42 12},
  pages={
          1617-23
        }
}
Growth hormone (GH) secretion is pulsatile in man and every other mammalian species that has been studied. The magnitude of pulses, their frequency, and their regularity vary. The receptor, on its part, undergoes cycles of internalization and recycling that are in synchrony with the frequency of GH pulses. This sequence of events has been shown to be advantageous to growth. It is suggested that changes in GH secretion dynamics secondarily lead to most of the changes in GH receptor abundance and… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-4 OF 4 CITATIONS