Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.

@article{Lin1997RegulationOT,
  title={Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.},
  author={S-F. Lin and Tomoo Yamate and Yasuto Taguchi and Victoria Z.C. Borba and Giuseppe Girasole and C A O'brien and Teresita Bellido and Etsuko Abe and Stavros C Manolagas},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 8},
  pages={
          1980-90
        }
}
Both estrogen and androgen exert their antiosteoporotic effects, at least in part, by inhibiting IL-6 production, thereby suppressing osteoclastogenesis. Several observations, however, suggest that besides increased IL-6 production, sensitivity of the osteoclastogenic process to this cytokine is altered after ovariectomy. Based on this and evidence that the ligand-binding subunit of the IL-6 receptor (gp80) is a limiting factor for the actions of IL-6 on bone, we hypothesized that sex steroids… CONTINUE READING
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