Regulation of the gap junction connexin 43 gene by androgens in the prostate.

@article{Huynh2001RegulationOT,
  title={Regulation of the gap junction connexin 43 gene by androgens in the prostate.},
  author={H. T. Huynh and Lesley Alpert and Dale W Laird and Gerald Batist and Lorraine E. Chalifour and Moulay A. Alaoui-Jamali},
  journal={Journal of molecular endocrinology},
  year={2001},
  volume={26 1},
  pages={1-10}
}
Androgens play an important role in prostate gland development and function, and have been implicated in prostate carcinogenesis. We report the regulation of the gap junctional intercellular communication gene connexin 43 (Cx43) by androgens in the prostate gland. In rat ventral prostate tissue, only trace levels of Cx43 mRNA were detected. Castration, however, resulted in a high increase in Cx43 mRNA and protein. Cx32 was unchanged. Castration-induced Cx43 mRNA and protein were abolished by… CONTINUE READING
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