Regulation of the fatty acid synthase promoter by insulin.

  title={Regulation of the fatty acid synthase promoter by insulin.},
  author={Hei Sook Sul and M J Latasa and Yang Soo Moon and Kang Ho Kim},
  journal={The Journal of nutrition},
  volume={130 2S Suppl},
Expression of critical enzymes in fatty acid and fat biosynthesis is tightly controlled by nutritional and hormonal stimuli. The expression of fatty acid synthase, which catalyzes all reactions for synthesis of palmitate from acetyl-CoA and malonyl-CoA, and of mitochondrial glycerol-3-phosphate acyltransferase, which catalyzes the first acylation step in glycerophospholipid synthesis, is decreased to an undetectable level during fasting. Food intake, especially a high carbohydrate, fat-free… CONTINUE READING