Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits.

  title={Regulation of the farnesoid X receptor (FXR) by bile acid flux in rabbits.},
  author={Guorong Xu and Lu-xing Pan and Hai Li and Barry Marc Forman and Sandra K. Erickson and Sarah Shefer and Jaya S Bollineni and Ashok Kumir Batta and Jennifer L Christie and T Wang and John Michel and Steve Yang and Richard Tsai and Lily Lai and Kohei Shimada and G. Stephen Tint and Gerald Salen},
  journal={The Journal of biological chemistry},
  volume={277 52},
We investigated the roles of hydrophobic deoxycholic acid (DCA) and hydrophilic ursocholic acid (UCA) in the regulation of the orphan nuclear farnesoid X receptor (FXR) in vivo. Rabbits with bile fistula drainage (removal of the endogenous bile acid pool), rabbits with bile fistula drainage and replacement with either DCA or UCA, and intact rabbits fed 0.5% cholic acid (CA) (enlarged endogenous bile acid pool) were studied. After bile fistula drainage, cholesterol 7alpha-hydroxylase (CYP7A1… CONTINUE READING