Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers

@article{GarcaFuster2008RegulationOT,
  title={Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers},
  author={M. Julia Garc{\'i}a-Fuster and Alfredo Ramos-Miguel and Guadalupe Rivero and Romano La Harpe and J. Javier Meana and Jes{\'u}s A Garc{\'i}a-Sevilla},
  journal={Neuroscience},
  year={2008},
  volume={157},
  pages={105-119}
}
Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behavioral sensitization, vulnerability to compulsive relapse, and high mortality. In laboratory animals, the potential effect of opiate drugs to induce cell death by apoptosis is a controversial topic. This postmortem human brain study examined the status of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of a large group of well-characterized heroin or methadone abusers. In… Expand
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