Regulation of the expression or recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase.

@article{SimbulanRosenthal1998RegulationOT,
  title={Regulation of the expression or recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase.},
  author={Cynthia Marie Simbulan-Rosenthal and David S. H. Rosenthal and A Hamid Boulares and Robert J. Hickey and Linda H. Malkas and Jennifer M. Coll and Mark E. Smulson},
  journal={Biochemistry},
  year={1998},
  volume={37 26},
  pages={
          9363-70
        }
}
Poly(ADP-ribose) polymerase (PARP) is a component of the multiprotein DNA replication complex (MRC, DNA synthesome) that catalyzes replication of viral DNA in vitro. PARP poly(ADP-ribosyl)ates 15 of the approximately 40 proteins of the MRC, including DNA polymerase alpha (DNA pol alpha), DNA topoisomerase I (topo I), and proliferating-cell nuclear antigen (PCNA). Although about equal amounts of MRC-complexed and free forms of PCNA were detected by immunoblot analysis of HeLa cell extracts, only… CONTINUE READING
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