Regulation of the expression of pigment epithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines.

@article{Miyagishi2003RegulationOT,
  title={Regulation of the expression of pigment epithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines.},
  author={Daisuke Miyagishi and Kyoko Ohno-Matsui and Teruo Amagasa and Ikuo Morita},
  journal={Cancer letters},
  year={2003},
  volume={196 1},
  pages={77-85}
}
Angiogenesis plays an important role in tumor growth and metastasis and is regulated by a balance between angiogenic stimulators and inhibitors. We investigated the gene expression profile of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), a potent endogenous anti-angiogenic factor, in human oral squamous cell carcinoma (SCC) cell lines. The treatment of SCC cells with hypoxia increased the expression of PEDF as well as VEGF. Moreover, the treatment of… CONTINUE READING

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