Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs.

@article{Lovis2008RegulationOT,
  title={Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs.},
  author={Pascal Lovis and Sonia Gattesco and Romano Regazzi},
  journal={Biological chemistry},
  year={2008},
  volume={389 3},
  pages={
          305-12
        }
}
Fine-tuning of insulin secretion from pancreatic beta-cells participates in blood glucose homeostasis. Defects in this process can lead to chronic hyperglycemia and diabetes mellitus. Several proteins controlling insulin exocytosis have been identified, but the mechanisms regulating their expression remain poorly understood. Here, we show that two non-coding microRNAs, miR124a and miR96, modulate the expression of proteins involved in insulin exocytosis and affect secretion of the beta-cell… CONTINUE READING
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