Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.

@article{Goldberg1988RegulationOT,
  title={Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein.},
  author={Mark A. Goldberg and S P Dunning and H. Franklin Bunn},
  journal={Science},
  year={1988},
  volume={242 4884},
  pages={1412-5}
}
Erythropoietin (Epo), the hormone that stimulates red blood cell production, is synthesized in the kidney and liver in response to hypoxia. The human hepatoma cell line Hep3B regulates its production of Epo in a physiologic manner. Either hypoxia or cobalt chloride markedly increases expression of Epo mRNA as well as production of biologically active and immunologically distinct Epo protein. New protein synthesis is required before the induction of increased levels of hypoxia- or cobalt-induced… CONTINUE READING
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