Regulation of the epithelial sodium channel by phosphatidylinositides: experiments, implications, and speculations

@article{Ma2007RegulationOT,
  title={Regulation of the epithelial sodium channel by phosphatidylinositides: experiments, implications, and speculations},
  author={He-ping Ma and Chu-Fang Chou and S Wei and Douglas C. Eaton},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2007},
  volume={455},
  pages={169-180}
}
Recent studies suggest that the activity of epithelial sodium channels (ENaC) is increased by phosphatidylinositides, especially phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). Stimulation of phospholipase C by either adenosine triphosphate (ATP)-activation of purinergic P2Y receptors or epidermal growth factor (EGF)-activation of EGF receptors reduces membrane PI(4,5)P2, and consequently decreases ENaC activity. Since ATP and EGF… CONTINUE READING

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