Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3.

Abstract

Epithelial calcium (re)absorption is mediated by TRPV5 and TRPV6 channels. TRPV5 is modulated by the SGK1 kinase, a process requiring the PDZ-domain containing scaffold protein NHERF2. The present study explored whether TRPV6 is similarly regulated by SGKs and the scaffold proteins NHERF1/2. In Xenopus oocytes, SGKs activate TRPV6 by increasing its plasma… (More)

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@article{Boehmer2007RegulationOT, title={Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3.}, author={Charles R. Boehmer and Miguel N Palmada and Christian Kenngott and R. Lindner and Federica R. Klaus and Joseph B. Laufer and F. Lang}, journal={FEBS letters}, year={2007}, volume={581 29}, pages={5586-90} }