Regulation of the epithelial Na+ channel by aldosterone: open questions and emerging answers.

@article{Garty2000RegulationOT,
  title={Regulation of the epithelial Na+ channel by aldosterone: open questions and emerging answers.},
  author={Haim Garty},
  journal={Kidney international},
  year={2000},
  volume={57 4},
  pages={1270-6}
}
Aldosterone is the principal adrenal steroid controlling Na+ retention in amphibians and mammalians. It acts primarily by increasing the apical Na+ permeability through activation of the epithelial Na+ channel (ENaC). The cellular events mediating the hormonal action are mostly unknown. Early studies have provided evidence that the hormone functions to activate or translocate pre-existing channels by a yet undefined mechanism. In addition, enhanced de novo channel synthesis appears to take… CONTINUE READING

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