Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct.

@article{Bugaj2008RegulationOT,
  title={Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct.},
  author={Vladislav Bugaj and Oleh Pochynyuk and Elena Mironova and Alain Vandewalle and Jorge Luis Perez Medina and James D Stockand},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={295 4},
  pages={F1063-70}
}
We used patch-clamp electrophysiology to investigate regulation of the epithelial Na+ channel (ENaC) by endothelin-1 (ET-1) in isolated, split-open rat collecting ducts. ET-1 significantly decreases ENaC open probability by about threefold within 5 min. ET-1 decreases ENaC activity through basolateral membrane ETB but not ETA receptors. In rat collecting duct, we find no role for phospholipase C or protein kinase C in the rapid response of ENaC to ET-1. ET-1, although, does activate src family… CONTINUE READING

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Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention.

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