Regulation of the endothelial apelin/APJ system by hemodynamic fluid flow.

@article{Busch2015RegulationOT,
  title={Regulation of the endothelial apelin/APJ system by hemodynamic fluid flow.},
  author={Raila Busch and Anne Strohbach and Malte Pennewitz and Florian Lorenz and Martin Bahls and Mathias C Busch and Stephan B. Felix},
  journal={Cellular signalling},
  year={2015},
  volume={27 7},
  pages={1286-96}
}
Although the apelin/APJ system is abundantly expressed in vascular endothelial cells (EC), it has not yet been considered to be regulated by fluid flow. The aim of this study was to explore the influence of shear stress on the expression of apelin/APJ in human EC. Therefore, gene and protein expression were assessed after flow exposure; cell supernatants were collected for measurements of NO and apelin; APJ or apelin knockdown were performed using siRNA. Our data show that gene and protein… CONTINUE READING
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