Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity.

@article{Schmitt2001RegulationOT,
  title={Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity.},
  author={Marcus M Schmitt and Ralf Kubitz and S Lizun and Matthias Wettstein and Dieter H{\"a}ussinger},
  journal={Hepatology},
  year={2001},
  volume={33 3},
  pages={509-18}
}
Canalicular transport via the bile salt export pump (Bsep) represents the rate-controlling step in taurocholate excretion, whose capacity is under osmotic control. The short-term effects of anisoosmolarity and Ca(2+)-withdrawal on the localization of Bsep and the tight junction proteins Zo-1 and occludin were studied in perfused rat liver by immunohistochemistry, confocal microscopy, and densitometry. Under normoosmotic conditions, Bsep was found in the canalicular membrane and showed a… CONTINUE READING
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