Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation

@article{Alessandrini1997RegulationOT,
  title={Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation},
  author={Alessandro Alessandrini and D. S. Chiaur and Michele Pagano},
  journal={Leukemia},
  year={1997},
  volume={11},
  pages={342-345}
}
The cell cycle has been the object of extensive studies for the past years. A complex network of molecular interactions has been identified. In particular, a class of cell cycle inhibitory proteins has been cloned and characterized but details of the molecular mechanism of their action have yet to be resolved. These inhibitors regulate the progression through G1 and the G1/S transition via the inhibition of the cyclin-dependent kinase (Cdk) activity. The potential function of these negative… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 39 references

Activation of the Erk1 gene product requires phosphorylation on tyrosine and threonine . Procliferation inhibitors

  • M Pagano, P Beer-Romero, +7 authors R Erikson
  • Science
  • 1996

Assign - malian cells persists from the end of mitosis until the onset of S phase

  • M Brandeis, T Hunt, +10 authors B Vogelstein
  • EMBO J
  • 1996

Functions of the proteasome : the lysis at the end of the tunnel

  • AL Goldberg
  • Oncogene
  • 1996

Inactivation of the cdk inhibitor p27Kip1 by the human papillomavirus 16 E7 oncoprotein

  • P. Dürr
  • Oncogene
  • 1996

Role of the ubiquitinproteasome pathway in regulating abundance of the cyclindependentincreased body size , multiple organ hyperplasia , retinal dysplasia , and pituitary tumors

  • M Pagano, SW Tam, +13 authors M Rolfe
  • Genes Dev
  • 1996

Ubiquitination of the G 1 cyclin Cln 2 p by a Cdc 34 pdependent pathway

  • RJ Deshaies, V Chau, MW Kirschner
  • Cancer Res
  • 1996

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