Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation

  title={Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation},
  author={Alessandro Alessandrini and D. S. Chiaur and Michele Pagano},
The cell cycle has been the object of extensive studies for the past years. A complex network of molecular interactions has been identified. In particular, a class of cell cycle inhibitory proteins has been cloned and characterized but details of the molecular mechanism of their action have yet to be resolved. These inhibitors regulate the progression through G1 and the G1/S transition via the inhibition of the cyclin-dependent kinase (Cdk) activity. The potential function of these negative… CONTINUE READING


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