Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.

@article{Takada2005RegulationOT,
  title={Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.},
  author={Tappei Takada and Hiroshi Suzuki and Yukiko Gotoh and Yuichi Sugiyama},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2005},
  volume={33 7},
  pages={
          905-9
        }
}
Human breast cancer resistance protein (BCRP/ABCG2) is believed to act as an efflux pump to protect the body from drugs and toxins. BCRP is known to accept many kinds of endogenous and exogenous compounds as substrates and to be localized on the apical membrane of various tissues. Expression of BCRP is also reported on the side population cells, and a recent report suggested involvement of Akt in the modulation of the side population phenotype. In the present study, we have characterized the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL