Regulation of the cell cycle machinery by oncogenic ras.

  title={Regulation of the cell cycle machinery by oncogenic ras.},
  author={J T Winston and Stephen R. Coats and Yue Zeng Wang and Warren J Pledger},
  volume={12 1},
The ras proto-oncogene has been implicated during the formation of tumors in vivo as well as the transformation of cell lines in culture. Conditional expression of an activated ras mutant in Balb/c-3T3 fibroblasts failed to stimulate S phase entry in the absence of plasma-derived progression factors, but did shorten the G1 interval from 12 to 6 h and abrogate the normal proliferative requirement for platelet-derived growth factor. Ras-dependent alteration of the 3T3 cell cycle was accompanied… CONTINUE READING