Regulation of the cell cycle by B-Myb.

  title={Regulation of the cell cycle by B-Myb.},
  author={Maria Bessa and Manel Joaquin and Fiona J Tavner and Mark K. Saville and Roger J. Watson},
  journal={Blood cells, molecules & diseases},
  volume={27 2},
B-Myb is a cell-cycle-regulated member of the Myb transcription factor and, like c-Myb, has been implicated in regulation of hematopoietic cell proliferation and differentiation. In this study we have examined the mechanisms by which B-Myb regulates the cell cycle. We found that the ability of B-Myb both to promote Saos-2 cells into the S phase of the cell cycle and to overcome G1 arrest mediated by overexpression of the retinoblastoma-related p107 protein was correlated with the capacity of B… CONTINUE READING