Regulation of the calpain-calpastatin system by membranes (review).

  title={Regulation of the calpain-calpastatin system by membranes (review).},
  author={Hiroko Kawasaki and Seinosuke Kawashima},
  journal={Molecular membrane biology},
  volume={13 4},
Calpain, an intracellular calcium-dependent protease, is activated at cell membranes and cleaves cytoskeletal and submembranous proteins. Calpain is inferred to be a calcium-dependent regulator for cytoskeletal reorganization. Calpastatin, an endogenous calpain inhibitor, inhibits not only the proteolytic activity of calpain but also the binding of calpain to membranes. Calpain activity is strictly regulated by calcium and calpastatin. Calpain has two distinct sites for interaction with… CONTINUE READING

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