Regulation of the cadA cadmium resistance determinant of Staphylococcus aureus plasmid pI258.

@article{Yoon1991RegulationOT,
  title={Regulation of the cadA cadmium resistance determinant of Staphylococcus aureus plasmid pI258.},
  author={K. Paul Yoon and Tapan K. Misra and Simon Silver},
  journal={Journal of bacteriology},
  year={1991},
  volume={173 23},
  pages={7643-9}
}
Regulation of the cadA cadmium and zinc resistance determinant of Staphylococcus aureus plasmid pI258 was demonstrated by using gene fusions and direct measurements of transcription. In growth experiments, cells harboring the intact cadA operon were induced with different cations and challenged by an inhibitory concentration of ZnCl2, a substrate of the CadA resistance system. Uninduced cells did not grow for 8 h after Zn2+ addition, whereas induced cells grew in the presence Zn2+. Cd2+ was a… CONTINUE READING

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