Regulation of the cAMP-Dependent Chloride Current in Cardiac Ventricular Myocytes

@inproceedings{Harvey1992RegulationOT,
  title={Regulation of the cAMP-Dependent Chloride Current in Cardiac Ventricular Myocytes},
  author={Robert D. Harvey and Jonas A. Jurevi{\vc}ius and Joseph R. Hume},
  year={1992}
}
The contribution, if any, of Cl− to the electrical activity in cardiac muscle has been debated since the first reports that altering the extracellular Cl− concentration caused changes in the shape of the action potential and rate of spontaneous depolarization in Purkinje fibers (Nutter and Noble, 1961; Carmeliet, 1961). However, it was not until recently that conclusive evidence for a cardiac Cl− conductance was found in ventricular myocytes (Harvey and Hume, 1989a; Bahinski et al., 1989). One… CONTINUE READING
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