Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.

  title={Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.},
  author={S. Kajimura and P. Seale and T. Tomaru and H. Erdjument-Bromage and M. Cooper and J. Ruas and S. Chin and P. Tempst and M. Lazar and B. Spiegelman},
  journal={Genes & development},
  volume={22 10},
  • S. Kajimura, P. Seale, +7 authors B. Spiegelman
  • Published 2008
  • Biology, Medicine
  • Genes & development
  • Brown fat is a specialized tissue that can dissipate energy and counteract obesity through a pattern of gene expression that greatly increases mitochondrial content and uncoupled respiration. PRDM16 is a zinc-finger protein that controls brown fat determination by stimulating brown fat-selective gene expression, while suppressing the expression of genes selective for white fat cells. To determine the mechanisms regulating this switching of gene programs, we purified native PRDM16 protein… CONTINUE READING
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