Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae.

  title={Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae.},
  author={Matthew D. W. Piper and Seung Pyo Hong and Graham E Ball and Ian W. Dawes},
  journal={The Journal of biological chemistry},
  volume={275 40},
One-carbon metabolism in yeast is an essential process that relies on at least one of three one-carbon donor molecules: serine, glycine, or formate. By a combination of genetics and biochemistry we have shown how cells regulate the balance of one-carbon flow between the donors by regulating cytoplasmic serine hydroxymethyltransferase activity in a side reaction occurring in the presence of excess glycine. This control governs the level of 5,10-methylene tetrahydrofolate (5,10-CH(2)-H(4)folate… CONTINUE READING
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