Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.

@article{Kimura1998RegulationOT,
  title={Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.},
  author={Kazushi Kimura and Yuko Fukata and Yoichiro Matsuoka and Vann Bennett and Yoshiharu Matsuura and Katsuya Okawa and Akihiro Iwamatsu and Kozo Kaibuchi},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 10},
  pages={5542-8}
}
The small GTPase Rho is believed to regulate the actin cytoskeleton and cell adhesion through its specific targets. We previously identified the Rho targets: protein kinase N, Rho-associated kinase (Rho-kinase), and the myosin-binding subunit (MBS) of myosin phosphatase. Here we purified MBS-interacting proteins, identified them as adducin, and found that MBS specifically interacted with adducin in vitro and in vivo. Adducin is a membrane-skeletal protein that promotes the binding of spectrin… CONTINUE READING
65 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Similar Papers

Loading similar papers…