Regulation of the adrenocortical stem cell niche: implications for disease

  title={Regulation of the adrenocortical stem cell niche: implications for disease},
  author={Elisabeth M. Walczak and Gary D Hammer},
  journal={Nature Reviews Endocrinology},
Stem cells are endowed with the potential for self-renewal and multipotency. Pluripotent embryonic stem cells have an early role in the formation of the three germ layers (ectoderm, mesoderm and endoderm), whereas adult tissue stem cells and progenitor cells are critical mediators of organ homeostasis. The adrenal cortex is an exceptionally dynamic endocrine organ that is homeostatically maintained by paracrine and endocrine signals throughout postnatal life. In the past decade, much has been… CONTINUE READING
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