• DOI:10.1146/ANNUREV.PH.45.030183.000315
• Corpus ID: 3039128

Regulation of the adrenal and gonadal microsomal mixed function oxygenases of steroid hormone biosynthesis.

@article{Fevold1983RegulationOT,
  title={Regulation of the adrenal and gonadal microsomal mixed function oxygenases of steroid hormone biosynthesis.},
  author={H. Richard Fevold},
  journal={Annual review of physiology},
  year={1983},
  volume={45},
  pages={
          19-36
        }
}

• H. Fevold
• Published 1983
• Biology, Chemistry
• Annual review of physiology

The microsomal steroidogenic enzymes catalyze reactions important in determining both the quantity and the identity of glandular secretory prod­ ucts. By determining cell function, changes in the rates of these reactions can effect differentiation. The recognition of these control points in steroid hormone biosynthesis lagged because major research effort was directed at the rate-limiting reaction, mitochondrial cholesterol side-chain cleavage (140). The mechanism of the control of this site of tropic hormone action has been recently reviewed (132). A cell can alter the rates of the individual steps in steroidogenesis in several ways. The two most thoroughly documented are at the extremes­ modulation of gene expression and direct modulation of enzyme activity by inhibition. More nebulous and tantalizing are the possibilities for regulation of the amount of specific enzyme protein at a post-transcriptional or transla­ tion site and the regulation of enzyme activity or specificity by post-transla­ tional modification�ither covalent or protein-protein interaction. The ubiquitous protein phosphorylation and the possible requirement for sub­ strate binding specificity proteins to allow interaction with different sub­ strates are the most obvious examples of the latter. Here I review the control of the adrenal and gonadal microsomal roixed­ function oxygenase enzymes that catalyze the reactions leading to the major