Regulation of the adrenal and gonadal microsomal mixed function oxygenases of steroid hormone biosynthesis.

  title={Regulation of the adrenal and gonadal microsomal mixed function oxygenases of steroid hormone biosynthesis.},
  author={H. Richard Fevold},
  journal={Annual review of physiology},
  • H. Fevold
  • Published 1983
  • Biology, Chemistry
  • Annual review of physiology
The microsomal steroidogenic enzymes catalyze reactions important in determining both the quantity and the identity of glandular secretory prod­ ucts. By determining cell function, changes in the rates of these reactions can effect differentiation. The recognition of these control points in steroid hormone biosynthesis lagged because major research effort was directed at the rate-limiting reaction, mitochondrial cholesterol side-chain cleavage (140). The mechanism of the control of this site of… 

The Influence of Age on Steroidogenic Enzyme Activities of the Rat Adrenal Gland: Enhanced Expression of Cholesterol Side-Chain Cleavage Activity*

It appears from the evidence presented that the activities of the steroidogenic enzymes are not responsible for the diminished capacity in corticosterone production seen with aging in the rat.

Genes for cytochrome P-450 and their regulation.

Recent studies employing recombinant DNA techniques to investigate the genetic and evolutionary relatedness of various cytochrome P-450 isozymes as well as the molecular basis for the induction phenomenon are described.

Metabolism and toxicity of xenobiotics in the adrenal cortex, with particular reference to 7,12-dimethylbenz(a)anthracene.

  • E. Hallberg
  • Biology, Chemistry
    Journal of biochemical toxicology
  • 1990
7-OHM-12-MBA has been demonstrated to uniquely generate selective and massive oxidation of mitochondrial glutathione in cultured rat adrenal cells and a working hypothesis involving a possible peroxidative mechanism is presented.

The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factors a

  • S. Levine
  • Biology
    Annals of the New York Academy of Sciences
  • 1994
Although the infant rat is capable of responding to stressful stimuli by day 15, circadian rhythmicity and feedback regulation are not yet fully developed until much later in development, the overall picture that emerges is that there are multiple differences in the neonatal neuroendocrine system that ensure that plasma CORT is suppressed.

Studies of human placental aromatase.

Heterogeneity of cytochrome P-450 in rat testis microsomes.

Steroidogenic activity of high molecular weight forms of corticotropin.

The high molecular weight forms of adrenocorticotropic hormone (ACTH) produced by mouse pituitary tumor cells (AtT-20/D-16v) were separated from each other by gel filtration; their ability to