Regulation of the activity of the type IC EcoR124I restriction enzyme.

@article{Kulik1996RegulationOT,
  title={Regulation of the activity of the type IC EcoR124I restriction enzyme.},
  author={Eva M. Kulik and Thomas A. Bickle},
  journal={Journal of molecular biology},
  year={1996},
  volume={264 5},
  pages={891-906}
}
Restriction-modification (R-M) systems must regulate the expression of their genes so that the chromosomal genome is modified at all times by the methyltransferase to protect the host cell from the potential lethal action of the cognate restriction endonuclease. Since type I R-M systems can be transferred to non-modified Escherichia coli cells by conjugation or transformation without killing the recipient, they must have some means to regulate their restriction activity upon entering a new host… CONTINUE READING