Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by platelet factor H.

@article{Devine1987RegulationOT,
  title={Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by platelet factor H.},
  author={Dana V. Devine and Wendell F. Rosse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 16},
  pages={5873-7}
}
The alternative pathway of complement is regulated on the surface of homologous blood cells at the C3 amplification step by the membrane protein decay-accelerating factor, as well as by the plasma protein factor H. We have reported elsewhere that platelets from patients with paroxysmal nocturnal hemoglobinuria regulate the activity of the C3 convertase C3bBb, even though they lack decay-accelerating factor. We now report that normal human platelets contain factor H, which was released from the… CONTINUE READING
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